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Trulicity vs Retatrutide: What to Do When One Fails At a glance Drug class (Trulicity) / GLP-1 receptor agonist (dulaglutide), once-weekly subcutaneous injection Drug class (Retatrutide) / GIP plus GLP-1 plus glucagon receptor triple agonist, once-weekly subcutaneous injection (Phase 3, not yet FDA-approved) Best weight loss (Trulicity) / 3.0 kg mean at 52 weeks in AWARD-11 high-dose arm Best weight loss (Retatrutide) / 24.2% mean body weight reduction at 48 weeks in Phase 2 (N=338) Cardiovascular outcome data / Trulicity: REWIND (N=9,901, Lancet 2019) showed 12% MACE reduction

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